2 edition of Myometrial differentiation during pregnancy. found in the catalog.
Myometrial differentiation during pregnancy.
Prudence Pui-Hing Tsui
Written in English
From a quiescent state in early pregnancy to a highly contractile state in labour, the myometrium displays tremendous growth and remodeling which is thought to occur as a result of phenotypic modulation of uterine smooth muscle cells (SMCs). This study tested the hypothesis that during pregnancy, phenotypic modulation of myometrial SMCs is regulated by endocrine and mechanical signals that are mediated by growth factors and cytokines, and the eventual onset of contractile phenotype is characterized by changes in contractile machinery. We demonstrated that the gene expression of growth factors (IGF system, TGFbeta family, EGFR), cytokines (Ccl2, HGF, Edn system), and contractile proteins (actins, alpha-Tpm, SM22alpha) were affected by pregnancy in the rat myometrium. They were differentially expressed associated with particular phase(s) of myometrial differentiation. Furthermore, TGFbeta3 protein expression was found to be stretch-regulated near term. Taken together, these results suggest that programmed differentiation of myometrial SMCs is regulated by growth factors, cytokines, and contractile proteins.
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Arrows represent myometrial contractions both anteriorly and posteriorly. Lower arrows delineate the cervix. Uterine contraction and fibroid in the same patient. Note the change in configuration of the placenta during the scan once the contraction began resolving. Uterine contraction and fibroid in the same patient (Case 2). myometrial oxytocin receptor density increases during pregnancy and labor, the precise con-trols of this up-regulation are unknown For many years, synthetic oxytocic agents have been successfully used in the third stage both to prevent and to treat postpartum hemor-rhage. At the same time, however, therapeutic oxytocic agents used to augment.
during pregnancy by exogenous P (51). The female hamster, like the rat, has been used extensively to study the hormonal con- trol mechanisms that are operative during pregnancy . Myometrial Pathology •Leiomyoma •Lipoleiomyoma •Leiomyosarcoma •Adenomyosis cycles, during pregnancy, with Tamoxifen and in post menopausal woman on hormone replacement. •Well differentiated with slow progression seen in woman
Clinical Practice GUIDELINES Pocketcards. Official American Thyroid Association Practice GUIDELINES Pocketcards quick reference-tools provide your physicians, fellows, nurses, and students with instant access to current ATA guidelines information in a clear concise format. The human uterus undergoes profound physiological tissue remodelling during pregnancy. In the myometrium, altered gene expression must underlie these extensive molecular and structural changes. The purpose of this study was to compare expression profiles of pregnant and non-pregnant myometrium, in order to identify genes that participate in this process. .
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During early to mid-pregnancy in rats there is a high rate of myometrial cell proliferation and hyperplasia, exemplified by increased BrdU incorporation and PCNA staining in the longitudinal smooth muscle layer.
This declines precipitously by 17 dpc (term = 23 dpc) and is accompanied by an increase in cellular : Carole R. Mendelson, Lu Gao, Alina P. Montalbano. Melanin production during pregnancy may also darken or discolor skin on the face to create a chloasma, or “mask of pregnancy.” Figure Linea Nigra The linea nigra, a dark medial line running from the umbilicus to the pubis, forms during pregnancy and persists for a few weeks following childbirth.
Myometrial phenotypes during pregnancy and labour. The myometrial cells exhibit a programmed pattern of distinct phenotypes throughout pregnancy, labour and postpartum. These include (1) an initial proliferative phenotype in which myocytes undergo hyperplasia; (2) a synthetic phase involving myocytes hypertrophy, Cited by: Neonatal exposure to endosulfan induced morphological and molecular alterations in the myometrium at early pregnancy.
• Endosulfan altered myometrial adaptation during labor by increasing the expression of contraction-associated genes. • Endosulfan altered the timing of parturition by inducing advancement in the initiation of by: 1.
Myometrial adaptation during early pregnancy is characterized by hyperplasia of SMCs. It has been reported that high rate of myometrial cell proliferation in early pregnancy reflects important aspects of many smooth muscle populations during development, and that is induced by estrogen-regulated growth factors (Shynlova et al., ).
In our work, lower myometrial proliferation was associated with a downregulation of myometrial Cited by: 1. In vitro myometrial active, and passive, length-tension curves shifted significantly to the right during pregnancy indicative of altered mechanosensitivity; at term, maximum active tension was generated following ± fold stretch beyond slack length compared to ± fold for NP mice.
Moreover, mechanotransduction was altered during pregnancy as evidenced by Cited by: Acknowledged authorities from around the world discuss a wealth of material including cell and developmental biology, structure, function, anatomy and endocrinology, and clinically important issues such as the cervix during pregnancy, measurement.
To address this issue, we defined the expression and hormonal regulation of AP-1 genes in the rat myometrium during pregnancy and labor.
Tissue. The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells.
The diagnosis of myometrial involvement is relatively simple early in the first trimester of pregnancy and is based on the visualization of the gestational sac, which extends into the myometrium beyond the EMJ. On Doppler examination, the blood supply to the pregnancy is usually more abundant than in cases of normal intrauterine implantation Cited by: Myometrial contractions, or afterpains, assist in involution.
These contractions occur during the first 2–3 days of the puerperium and produce more discomfort in multiparas than in primiparas. Such pains are accentuated during nursing as a result. Relative abundance of the Igf1 and Igf2 gene transcripts in the myometrium is shown in Figure 1.
Igf1 mRNA was detected in NP myometrial samples. Igf1 gene expression was induced predominantly during early pregnancy, the proliferative phase of myometrial Cited by: Mammalian Target of Rapamycin Is Activated in Association with Myometrial Proliferation during Pregnancy Article in Endocrinology (10).
Myometrial contractions can be differentiated from leiomyomas or adenomyomas by sequential studies thanks to their transient nature. Visualization of physiological variations of the junctional zone on MRI images is dependent on the patient's age and hormonal status (contraceptive pills, gonadotropin-releasing hormone agonist [GnRHa Cited by: 9.
Evidence for fibronectin role on uterine Natural Killer cells migration, proliferation, differentiation and survival during pregnancy. Chapter (PDF Available) July with 28 Reads How we.
Myometrial Activation. During pregnancy, for the most part, the myometrium is quiescent, with the exception of irregularly timed, brief Braxton-Hicks contractions. The uterus in its quiescent state is relatively non-responsive to stimulation of contraction.
The last phase of myometrial differentiation is postpartum uterine involution, completing the reproductive cycle following pregnancy and labour by returning the uterus to its non-pregnant Cited by: 1) the myometrial transcriptome of patients with an AODIL has been characterized; differential expression of 42 genes was identified; 2) Gene Ontology analysis revealed enrichment of multiple biological processes and molecular functions impacting regulation of angiogenesis, response to hypoxia, inflammatory response, chemokine-mediated signaling pathway, apoptosis, stress Cited by: Background.
Intramural pregnancy is a rare form of ectopic pregnancy, difficult to diagnose and generally complicated by uterine rupture. Case. A year-old woman, gravida 5 para 1, was diagnosed with intramural pregnancy by ultrasound and confirmed with MRI.
A uterine rupture occurred, which lead to laparotomy and a conservative treatment. by: 9. Shynlova O, Tsui P, Dorogin A, Langille BL, Lye SJ () Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat.
Biol Reprod – PubMed CrossRef Google ScholarCited by: 3. The myometrial smooth muscle is arranged into three ill-defined layers. Myometrium is hormone sensitive and undergoes both hypertrophy (an increase in cell size) and hyperplasia (an increase in cell numbers) during pregnancy (Fig.
), progressively returning to its normal size (involution) in the weeks after delivery.Stro-1/CD44 as putative human myometrial and fibroid stem cell markers Regulation of myometrial functions during pregnancy has been considered the result of the integration of endocrine and.Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat.
Biol Reprod ; 76 (4) ; 13 Tanwar PS, Lee HJ, Zhang L, et al. Constitutive activation of beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice Cited by: 3.